Several years ago, Collins, Stokes, and MIT Professor Regina Barzilay (who is also an author on the new study), set out to combat this growing problem by using machine learning, a type of artificial intelligence that can learn to recognize patterns in vast amounts of data. Over the past several decades, many pathogenic bacteria have become increasingly resistant to existing antibiotics, while very few new antibiotics have been developed. The paper’s lead authors are McMaster University graduate students Gary Liu and Denise Catacutan and recent McMaster graduate Khushi Rathod. baumannii.”Ĭollins and Stokes are the senior authors of the new study, which appears today in Nature Chemical Biology. “I’m excited that this work shows that we can use AI to help combat problematic pathogens such as A. ![]() “This finding further supports the premise that AI can significantly accelerate and expand our search for novel antibiotics,” says James Collins, the Termeer Professor of Medical Engineering and Science in MIT’s Institute for Medical Engineering and Science (IMES) and Department of Biological Engineering. The researchers identified the new drug from a library of nearly 7,000 potential drug compounds using a machine-learning model that they trained to evaluate whether a chemical compound will inhibit the growth of A. baumannii isolates that are resistant to nearly every antibiotic,” says Jonathan Stokes, a former MIT postdoc who is now an assistant professor of biochemistry and biomedical sciences at McMaster University. “ Acinetobacter can survive on hospital doorknobs and equipment for long periods of time, and it can take up antibiotic resistance genes from its environment. The microbe is also a leading cause of infections in wounded soldiers in Iraq and Afghanistan. If developed for use in patients, the drug could help to combat Acinetobacter baumannii, a species of bacteria that is often found in hospitals and can lead to pneumonia, meningitis, and other serious infections. ![]() We are the only Canadian host site of a United Nations University (The Institute for Water, Environment and Health- UNU-INWEH) and are committed to engaging in issues that affect not only Canada, but the world.Using an artificial intelligence algorithm, researchers at MIT and McMaster University have identified a new antibiotic that can kill a type of bacteria that is responsible for many drug-resistant infections. With students and faculty from well over 90 countries worldwide and 70 international exchange agreements in place, we celebrate diversity and welcome international perspectives. Home to some of the best minds and laboratories in the country, with research output rivalling universities more than twice its size, McMaster has a well-deserved reputation as a hotbed of discovery and innovation and is consistently ranked among Canada’s top research intensive universities.įrom combating disease to informing public policy, reducing environmental pollutants and manufacturing the next smart car, McMaster students and researchers are working collaboratively, across disciplines to address the most urgent needs in our society, improving quality of life, productivity and developing opportunities for communities across Canada and the world. In addition to McMaster’s renowned medical school, our professional schools in the Faculties of Engineering and Business are complimented by our commitment to teaching and research in the Faculties of Humanities, Social Sciences and Science. The McMaster community includes 21,441 undergraduate students, 3,519 graduate students, 1,413 full-time faculty and 170,654 alumni, based in 137 countries worldwide. One of only four Canadian Universities consistently ranked in the world’s top 100, McMaster has a proud tradition of academic and research excellence, evidenced by the achievements of our best and brightest whose ranks include three Nobel Prize winners, global business leaders, technological innovators, prominent politicians, public intellectuals, philanthropists and performers.Ī one-hour drive from Toronto and a one-hour flight from major American hubs New York City, Washington D.C and Chicago, our campus is located in the heart of one of the most vibrant and multicultural regions of North America. Since 1887, McMaster University has been dedicated to the cultivation of human potential, a commitment we demonstrate everyday through our ground-breaking approaches to teaching and learning and our world-class, interdisciplinary research.
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